Next-generation Sequencing Library Preparation Market Size & Trend Report, 2024-2033
The global next-generation sequencing library preparation market size was exhibited at USD 1.43 billion in 2023 and is projected to hit around USD 4.93 billion by 2033, growing at a CAGR of 13.18% during the forecast period 2024 to 2033.
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Key Takeaways:
Next-generation Sequencing Library Preparation Market by Overview
Next-Generation Sequencing (NGS) has revolutionized the genomics landscape, enabling unprecedented insights into genetic variations, transcriptomes, and epigenetic changes. Central to the success of NGS is the library preparation process, a critical step that significantly impacts the quality and reliability of sequencing data. This overview delves into the burgeoning market of NGS library preparation, highlighting its significance, growth drivers, challenges, and future prospects.
Next-generation Sequencing Library Preparation Market Growth
The growth trajectory of the Next-generation Sequencing (NGS) Library Preparation market is primarily driven by a confluence of factors that underscore its increasing relevance in genomics research and clinical diagnostics. Firstly, technological advancements have significantly enhanced the efficiency and scalability of NGS library preparation processes, facilitating faster sequencing with reduced costs. This has spurred adoption across academic research institutions, biopharmaceutical companies, and clinical laboratories aiming for high-throughput genomic analysis. Secondly, the expanding applications of NGS in personalized medicine, oncology, infectious diseases, and agricultural genomics have amplified demand for robust library preparation kits tailored to specific research objectives. Moreover, the rising prevalence of chronic diseases and genetic disorders necessitates comprehensive genomic profiling, further fueling market growth. Additionally, collaborations between academic institutions, industry players, and regulatory bodies are fostering innovation, standardization, and the development of novel library preparation methodologies. Lastly, increasing investments in genomics research and the integration of NGS technologies into routine clinical workflows are projected to propel the market forward, paving the way for transformative advancements in precision medicine and diagnostics.
Next-generation Sequencing Library Preparation Market Report Scope
| Report Coverage | Details |
| Market Size in 2024 | USD 1.43 Billion |
| Market Size by 2033 | USD 4.93 Billion |
| Growth Rate From 2024 to 2033 | CAGR of 13.18% |
| Base Year | 2023 |
| Forecast Period | 2024-2033 |
| Segments Covered | Sequencing Type, Product, Application, End-Use, Region |
| Market Analysis (Terms Used) | Value (US$ Million/Billion) or (Volume/Units) |
| Regional Scope | North America; Europe; Asia Pacific; Central and South America; the Middle East and Africa |
| Key Companies Profiled | Agilent Technologies, Inc., Integrated DNA Technologies, F. Hoffmann-La Roche AG, Inc., Illumina, Inc., Beckman Coulter Inc. (now part of Danaher Corporation), Becton, Merck KGaA, Dickinson and Company, New England Biolabs, Inc., PerkinElmer Inc., QIAGEN N.V., Pacific Biosciences of California, Inc., Thermo Fisher Scientific Inc., Tecan Group Ltd. |
Next-generation Sequencing Library Preparation Market Dynamics
The Next-generation Sequencing (NGS) Library Preparation Market Dynamics are significantly influenced by continuous technological advancements and innovation. As the demand for faster, more accurate, and cost-effective sequencing solutions intensifies, companies are investing heavily in research and development to enhance library preparation methodologies. Innovations such as streamlined workflows, automation, and multiplexing capabilities are driving efficiency gains, reducing turnaround times, and lowering per-sample costs. Furthermore, the introduction of novel enzymes, adapters, and library preparation kits optimized for various sequencing platforms and applications is expanding the market's scope. This relentless pursuit of innovation not only fosters competition among industry players but also catalyzes the adoption of NGS technologies across diverse sectors, including research, diagnostics, and personalized medicine.
Another pivotal dynamic shaping the NGS Library Preparation market is the expanding applications in genomics research and clinical diagnostics. With the increasing recognition of genomics as a cornerstone for understanding complex diseases, therapeutic development, and personalized medicine, the demand for comprehensive and reliable sequencing solutions has surged. NGS library preparation plays a critical role in facilitating high-throughput genomic analysis, enabling researchers and clinicians to extract meaningful insights from vast amounts of genomic data. Moreover, the integration of NGS technologies into clinical diagnostics workflows is transforming patient care by enabling precise molecular profiling, early disease detection, and treatment stratification. As a result, the growing adoption of NGS in oncology, infectious diseases, rare genetic disorders, and agricultural genomics is driving market growth and diversifying its application landscape.
Market Restraint
One of the significant restraints affecting the Next-generation Sequencing (NGS) Library Preparation market is the high initial capital investment and operational costs associated with implementing and maintaining NGS platforms. While technological advancements have led to cost reductions over time, the upfront expenses for acquiring state-of-the-art sequencing instruments, specialized equipment, and consumables remain substantial. Additionally, the need for skilled personnel, extensive computational resources for data analysis, and ongoing maintenance and upgrades further escalates operational expenditures. These cost constraints pose challenges for academic institutions, smaller research laboratories, and healthcare facilities with limited budgets, potentially limiting their access to advanced NGS technologies and hindering market penetration in emerging regions.
Another significant restraint in the NGS Library Preparation market is the complexity and standardization challenges associated with library preparation protocols and workflows. The intricate nature of sample preparation, library construction, and sequencing procedures necessitates meticulous attention to detail, rigorous quality control measures, and specialized expertise. Variability in methodologies, reagent formulations, and sequencing platforms across different manufacturers can lead to inconsistencies in results, affecting reproducibility and comparability of genomic data. Moreover, the lack of universally accepted standards and guidelines for library preparation and data interpretation complicates inter-laboratory collaborations, data sharing, and regulatory compliance. As a result, efforts to standardize protocols, enhance reproducibility, and establish consensus in the scientific community are essential to address these challenges and unlock the full potential of NGS technologies in genomics research and clinical applications.
Market Opportunity
A significant opportunity in the Next-generation Sequencing (NGS) Library Preparation market lies within emerging markets and untapped sectors that are increasingly recognizing the value of genomics research and personalized medicine. As awareness grows regarding the role of NGS technologies in advancing healthcare outcomes, academic research, and agricultural innovation, developing regions present lucrative growth prospects. These markets offer opportunities for market players to expand their footprint, establish strategic partnerships, and collaborate with local stakeholders to address region-specific challenges and unmet needs.
Another compelling opportunity in the NGS Library Preparation market is the advancements in precision medicine, therapeutic development, and targeted genomic interventions. As the understanding of genetic variability, disease mechanisms, and therapeutic responses deepens, the demand for personalized and targeted sequencing solutions continues to escalate. NGS library preparation plays a pivotal role in facilitating comprehensive genomic profiling, biomarker discovery, and patient stratification, enabling clinicians and researchers to develop tailored therapeutic strategies, optimize treatment protocols, and improve patient outcomes. Furthermore, the convergence of NGS technologies with artificial intelligence, machine learning, and data analytics is unlocking new opportunities for predictive modeling, drug discovery, and precision healthcare delivery.
Market Challenges
A significant challenge facing the next-generation sequencing (NGS) library preparation market is the complexity associated with data analysis and interpretation. As sequencing technologies evolve, generating vast volumes of genomic data has become more accessible and cost-effective. However, the computational infrastructure, bioinformatics tools, and expertise required to process, analyze, and derive meaningful insights from this data remain formidable hurdles. The complexity of integrating multi-dimensional genomic datasets, identifying clinically relevant variants, and translating genomic information into actionable insights for healthcare providers and researchers poses significant challenges. Additionally, ensuring data accuracy, reproducibility, and standardization across different sequencing platforms and analytical pipelines is essential but challenging. As a result, addressing these bioinformatics and data management challenges is crucial to harnessing the full potential of NGS technologies and facilitating their widespread adoption in diverse applications.
Another critical challenge in the NGS Library Preparation Market revolves around regulatory and ethical considerations governing genomic data generation, storage, sharing, and interpretation. The evolving regulatory landscape, stringent quality control requirements, and privacy concerns surrounding genomic data pose challenges for market players, researchers, and healthcare providers alike. Ensuring compliance with international standards, data protection regulations, and ethical guidelines while promoting data sharing, collaboration, and innovation is a delicate balancing act. Moreover, navigating the complexities of informed consent, data ownership, intellectual property rights, and patient privacy rights adds another layer of complexity to the regulatory landscape. As genomic research and clinical applications continue to advance, addressing these regulatory, legal, and ethical challenges is paramount to fostering public trust, ensuring data integrity, and unlocking the full potential of NGS technologies in improving healthcare outcomes.
By Segments
Sequencing Type Insights
Targeted sequencing held the largest share in 2023. Targeted sequencing facilitates the robust detection of commonly occurring and rare genetic variations that may be causative of a disease condition. It is also used for the detection of genetic aberrations that contribute to therapeutic drug responses and adverse effects in an individual. The growing global incidence of diseases and genetic disorders, including cancer, is contributing to the growth of the segment.
The WGS segment is anticipated to grow significantly during the forecast period. Lowered sequencing costs and analysis of genome-wide characteristics make whole-genome sequencing a powerful tool for genomics research. It is a comprehensive technique that is used for the analysis of the entire genome for detailed inference of inherited disorders, characterizing mutations, and tracing disease outbreaks. For instance, in December 2021, PacBio signed a collaboration with researchers at UCLA for advanced identification of the causes of rare diseases. The collaboration is intended to leverage PacBio’s Hi-Fi long-read sequencing technology for WGS to analyze undiagnosed pediatric rare diseases.
Products Insights
reagents and consumables held the largest share of 78% in 2023. NGS library preparation includes the construction of DNA and RNA sequence libraries, amplification, and quantification. Many players are collaboratively working towards the construction of specific libraries to yield the most favorable outcomes from sequencing, using appropriate laboratory reagents. For instance, in January 2023, Singular Genomics Systems, Inc. signed into a collaboration with Watchmaker Genomics to aid researchers and clinicians in validating its Watchmaker-DNA library preparation kits to be used with the G4 sequencing platform using NGS and multiomics technologies.
The instrument segment is anticipated to show a significant market share in 2023. The ability to produce huge amounts of data with sequencing makes WGS a powerful tool for genomics research. Moreover, the introduction of advanced and novel sequencing instruments boosted segment growth. For instance, in December 2023, Singular Genomics introduced the G4 sequencing platform. This novel platform will offer adjustable run capacity and up to three times the data output per hour of existing benchtop instruments.
Application Insights
The drug and biomarker discoveries held the largest share (62.17%) in 2023. Many companies are collaboratively working towards the construction of precise NGS libraries that yield the most favorable outcomes from sequencing using appropriate laboratory reagents. For instance, in September 2023, QIAGEN entered into a collaboration with Neuron23 for the development of NGS-based companion diagnostics using Neuron23’s proprietary molecule, a leucine-rich repeat kinase inhibitor, which is a brain penetrant used for the treatment of Parkinson’s disease. Qiagen will develop and validate a clinical trial assay that will essentially identify the combination of biomarkers identified by Neuron23, along with comprehensive support for drug development.
The disease diagnostics segment is anticipated to grow significantly during the forecast period. NGS reliably sequences all genes that are relevant to a given phenotype to precisely detect the causative contribution to a disease condition. Moreover, NGS performs simultaneous analysis of multiple genes, potentially saving time, money, and tissue if many potential markers are needed to be analyzed for a disease. For instance, in November 2023, Illumina Inc. announced the release of a novel NGS-based diagnostic test for the identification of genito-urinary pathogens and antimicrobial resistance using precision metagenomics for the detection and quantification of over 170 pathogens and more than 3700 markers associated with 18 different drug classes.
End-use Insights
The academics & research institutions segment held the highest market share in 2023. NGS-based high-throughput sequencing technologies have been extensively applied in specific research activities like gene-expression profiling, chromatin immune precipitation, and small-RNA sequencing to enhance the outcomes of biological and biomedical research. For instance, in March 2021, researchers at the University of California signed into a collaboration with Miroculus, Inc., and Purigen Biosystems for the development of a revolutionary tool for personal lab automation for the optimization of an automated PCR-free whole genome sequencing library preparation workflow with micro-input human samples.
The Hospital & Clinics segment is anticipated to grow significantly during the forecast period owing to the rising incidence of cancer, genetic disorders, and rare diseases across the globe. According to the Center for Disease Control (CDC), NGS has transitioned from research to clinical use in the past 5 years. Genome sequencing analysis is a preferred diagnostic step because its outcomes offer insights into the characteristic contribution of genes to a given disease condition.
Regional Insights
North America leads the global NGS library preparation market with a share of 50% in 2023.The growth of the market in the region is mainly attributed to extensive disease-based research studies sponsored by academic research institutes and pharmaceutical giants. For instance, in March 2021, Swift Biosciences signed into a collaboration with SPT Labtech for enhancement of Swift Biosciences' library preparation kits on mosquito genomics and dragonfly discovery platforms, so as to expand the portfolio of library preparation solutions for degraded DNA, low-input RNA, and custom amplicon panels.
The Asia Pacific is expected to grow considerably in the future due to the rising prevalence of rare diseases and high population density. Moreover, key market players are working towards entering the Asia Pacific market with their NGS library preparation expertise. For instance, in May 2021, BGI signed an agreement with the Ethiopian Biotechnology Institute to carryout pilot scale testing of HPV genotyping to establish a novel technique for HPV screening, diagnosis, and treatment.
Some of the prominent players in the next-generation sequencing library preparation market include:
Segments Covered in the Report
This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2024 to 2033. For this study, Nova one advisor, Inc. has segmented the global Next-generation sequencing library preparation market.
Sequencing Type
Products
Application
End-use
By Region
Cross-segment Market Size and Analysis for Mentioned Segments
Additional Company Profiles
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Additional Countries (Apart
From Mentioned Countries)
Country/Region-specific Report
Go To Market Strategy
Region Specific Market DynamicsRegion Level Market Share Import Export AnalysisProduction AnalysisOthers