Cell Line Development Market Size, Share & Trends Analysis Report By Product & Services (Reagents And Media, Equipment), By Source (Mammalian, Non-mammalian), By Type of Cell Line, By Source, By Application,- Global Industry Analysis, Share, Growth, Regional Outlook and Forecasts, 2024-2033

The global cell line development market size was exhibited at USD 5.81 billion in 2023 and is projected to hit around USD 14.95 billion by 2033, growing at a CAGR of 9.91% during the forecast period 2024 to 2033.

Key Takeaways:

  • North America held the largest market share of 39.22% of the global cell line development market in 2023.
  • Asia Pacific is expected to experience the fastest CAGR of 11.61% from 2024 to 2033
  • The reagents and media segment held the largest market share of 43.78% in 2023.
  • The services segment is expected to witness the fastest CAGR of 10.64% from 2024 to 2033.
  • The mammalian cell line segment held the largest market share of 72.62% in 2023.
  • The recombinant cell lines segment held the largest market share of 31.79% in 2023.
  • The hybridomas segment is expected to witness the fastest CAGR of 10.10% from 2024 to 2033.
  • The bioproduction segment held the largest market share of 47.0% in 2023.
  • The tissue engineering segment is expected to witness the fastest CAGR of 10.53% from 2024 to 2033.

Report Scope of The Cell Line Development Market

 Report Coverage  Details
Market Size in 2024 USD 6.39 Billion
Market Size by 2033 USD 14.95 Billion
Growth Rate From 2024 to 2033 CAGR of 9.91%
Base Year 2023
Forecast Period 2024-2033
Segments Covered Product & Services, Source, Type of Cell lines, Application, Region
Market Analysis (Terms Used) Value (US$ Million/Billion) or (Volume/Units)
Regional Scope North America; Europe; Asia Pacific; Central and South America; the Middle East and Africa
Key Companies Profiled Thermo Fisher Scientific Inc., Corning Inc., Lonza, Creative BioLabs., WuXi PharmaTech, Sartorius AG, Merck KGaA, Advanced Instruments, Berkeley Lights, Danaher

 

Cell line development (CLD) process is expected to be in high demand as the biopharmaceutical sector expands. The majority of biopharma businesses uses cells as an expression host for the synthesis of recombinant monoclonal antibodies and proteins. The availability of enhanced technologies to manufacture novel cell lines and an increase in demand for monoclonal antibodies and cancer therapies are projected to drive market expansion in coming years.

COVID-19 benefited the CLD market as a result of increased demand for vaccine research. According to a study published in March 2023, named “A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry”, the researchers have described the development of a suitable human cell line to conduct high-throughput testing of antiviral drugs that target the coronavirus 2 that causes severe acute respiratory syndrome (SARS-CoV-2). Two key host proteins necessary for viral entry, angiotensin-converting enzyme 2 (ACE2) & transmembrane serine protease 2 (TMPRSS2), were designed to express at high levels in the human lung cancer cell line A549. As a result, more cell lines were and are still being produced to handle COVID-19, which has significantly impacted the market during the pandemic period.

During the projection period, the expiration of blockbuster medications such as Lantus, Abilify, Namenda, & Androgel is likely to drive the development of new biosimilars. The growing number of R&D activities for biosimilars and biologic products, is predicted to drive demand for cell lines for large-scale production. In recent years, the US Food & Drug Administration (FDA) has authorized approximately 15 new proteins per year, including therapeutic & recombinant proteins. As a result, the rising need for innovative pharmaceuticals, vaccines, biosimilars, as well as therapeutic proteins is likely to drive the growth of the CLD market throughout the forecast period.

Cancer has been increasingly widespread in the last 10 years as a result of changes in dietary practices, a lack of physical exercise, and overall changes in lifestyle. Furthermore, as vaccine production expands & technology progresses, the requirement for cell line creation will rise. According to the American Cancer Society estimate, the overall number of new cancer cases in 2023 is approximately 1,958,310 and 609,820 cancer death in the U.S. Furthermore, due to the rising use of cell lines in the manufacturing of biological cancer drug substances, the CLD market is likely to grow over the forecast period. However, the presence of regulatory framework and ethical concern related to stem cell-based research restrain the market growth to a certain extend.

Moreover, the growing acceptance of novel biopharmaceutical medications, as well as a growth in the prevalence of chronic diseases, will drive demand for biopharmaceutical products. Innovative product offerings will arise from the increased use of cutting-edge technology, such as bio-recombinant proteins, in the treatment of numerous chronic diseases. The safety and efficacy of biopharmaceutical products, as well as their ability to cure diseases that were previously incurable, will increase the rate of adoption for CLD and further boost the market growth.

Segments:

Cell Line Development Market By Product & Services Insights

The reagents and media segment held the largest market share of 43.78% in 2023. due to its wide applications in areas such as bio production, regenerative medicines, tissue engineering, drug discovery, and toxicity testing. Reagent and media are indispensible component of cell culture & cell line development process and is cost intensive in nature. Hence, propelling the segment growth.

The services segment is expected to witness the fastest CAGR of 10.64% from 2024 to 2033. CLD services are expected to rise over time due to the rising demand for monoclonal antibodies, patent expiration of blockbuster biologics, increasing demand for effective cancer therapeutics and technological advancement in the field of CLD. Furthermore, the increasing trend of biologics outsourcing as well as rising approval & demand for biologics and biosimilars, are all providing the market with enormous growth opportunities.

Cell Line Development Market By Source Insights

The mammalian cell line segment held the largest market share of 72.62% in 2023. Cell line formation begins with organs or tissues obtained from mammals or non-mammalian sources. Cell line source selection is required for the production of commercially viable stable cell lines. Mammalian cell lines are most widely employed for the synthesis of monoclonal antibodies, vaccines, & biologics due to their increased complex protein expression capabilities. There are approximately 4,000 mammalian cell lines available, and research is ongoing to introduce a few more. Over the projected period, all of the aforementioned facts are expected to create a profitable growth framework for CLD from mammalian sources.

Mammalian cell culture techniques are developed to produce vaccines for diseases such as mumps, rubella, and measles in humans, and foot & mouth diseases in veterinary care. It is the fastest-growing segment due to efficient production of biopharmaceuticals by mammalian cell lines as they are capable of providing complex proteins expression similar to humans. This is expected to increase the revenue share of mammalian cell line source in thand e CLD market.

Cell Line Development Market By Type of Cell Line Insights

The recombinant cell lines segment held the largest market share of 31.79% in 2023. due to its extensive use in biologics production processes, gene activation, and protein interactions. In the upcoming years, it is also projected that increased demand would fuel the need for drug screening and toxicity testing. The main driver of the rising adoption of recombinant proteins throughout the projection period is the demand for biologics to treat cancer and autoimmune illnesses. These products include enzymes, blood components, hormones, monoclonal antibodies, and chemicals connected to antibodies. Over 400 of the 650 protein therapies that have received global approval are recombinant products.

The hybridomas segment is expected to witness the fastest CAGR of 10.10% from 2024 to 2033. The market for hybridomas is expected to show lucrative growth over the forecast period due to advantages associated with it such as ability to grow continuously, combination of two different types of cells, and production of pure antibodies on a large-scale. In addition, continuous advancement in the hybridoma technology such as use of feeder layers that consist of murine peritoneal cells and macrophages derived from mouse is expected to fuel this market growth over the forecast period.

Cell Line Development Market By Application Insights

The bioproduction segment held the largest market share of 47.0% in 2023. This attributed to the increased demand for drugs and vaccine production. The bioproduction technology area comprises the production of biologics-based treatment drugs such as vaccines, therapeutic proteins, cell therapies, along with gene therapies. The most common uses of bioproduction are producing biologics & vaccine, and demand is predicted to grow dramatically in the future owing to the increase in viral & communicable illnesses, particularly in developing nations.

The tissue engineering segment is expected to witness the fastest CAGR of 10.53% from 2024 to 2033. Growing adoption rates of tissue engineering in patient treatment such as implantation of bladders, skin grafts, small arteries, trachea, and cartilage, and increasing awareness related to personalized medicine are the factors contributing the market growth. In addition, rising awareness pertaining to regenerative medicines in which tissue or organ is safely grown in laboratory conditions with the help of cell culture techniques and then implanted are further expected to provide growth platform to this segment.

Cell Line Development Market By Regional Insights

North America held the largest market share of 40.0% of the global cell line development market in 2023. Owing to the increasing adoption rates of cell culture techniques due to advantages associated with it such as cost effectiveness and high productivity. The presence of sophisticated healthcare infrastructure, growing demand for biologics and increasing awareness related to cell therapy coupled with relatively higher healthcare expenditure levels in the region are the factors contributing towards the market growth.

Asia Pacific is expected to experience the fastest CAGR of 11.61% from 2024 to 2033 Key factors such as presence of untapped opportunities, economic development, improving healthcare infrastructure, and favorable initiatives by government and manufacturers in biotechnology sector are some factors accounting for this rapid growth. Furthermore, increasing median age of the population, rising production of vaccines, therapeutic proteins and others are the factors contributing to the overall growth of CLD market.

Some of the prominent players in the Cell line development market include:

  • Thermo Fisher Scientific Inc.
  • Danaher
  • Sartorius AG
  • Merck KGaACorning Inc.
  • Lonza
  • Creative BioLabs.
  • WuXi PharmaTech
  • Advanced Instruments
  • Berkeley Lights

Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Nova one advisor, Inc. has segmented the global cell line development market.

Product & Service

  • Reagents and media
  • Equipment
    • Automated Systems
    • Centrifuges
    • Bioreactors
    • Storage equipment
    • Others
  • Accessories and consumables
  • Services

Source

  • Mammalian cell line
  • Non-mammalian cell line
    • Insects
    • Amphibians

Type of Cell Lines

  • Recombinant cell lines
  • Hybridomas
  • Continuous cell lines
  • Primary cell lines

Application

  • Bioproduction
  • Drug discovery
  • Toxicity testing
  • Tissue engineering
  • Others

By Region

  • North America
  • Europe
  • Asia-Pacific
  • Latin America
  • Middle East & Africa (MEA)

Frequently Asked Questions

The global cell line development market size was exhibited at USD 6.51 billion in 2022 and is projected to hit around USD 17.52 billion by 2032

The global cell line development market is growing at a compound annual growth rate (CAGR) of 10.4% from 2023 to 2032.

North America cell line development business captured over 34% market share in 2022.

American Type Culture Collection (ATCC) (U.S.), Lonza Group AG (Switzerland), Thermo Fisher Scientific, Inc. (U.S.), GE Healthcare (U.K.), Sigma-Aldrich Corporation (U.S.), Selexis SA (Switzerland), European Collection of Cell Cultures (ECACC) (U.K.), Corning, Inc. (U.S.), WuXi AppTec, Inc. (China), and Sartorious AG (Germany).

We have a global reach, with expertise spanning across continents, including North America, Europe, Asia-Pacific, Latin America, and the Middle East. We leverage a combination of primary and secondary research methodologies to offer country-level analysis.

We conduct cross-sectional analysis by examining data from different individuals at a single point in time to identify patterns and trends across diverse segments of the market.

Our experienced team works closely with clients to gain a thorough understanding of their business goals and target markets. We have the expertise and flexibility to develop bespoke research solutions.

Our team of experienced analysts is available to address any questions, concerns and needs that may arise following the delivery of the report.

Through a combination of quantitative and qualitative research methodologies, we meticulously assess the strengths, weaknesses, strategies, and market positioning of your competitors.

Chapter 1. Methodology and Scope

1.1. Market Segmentation and Scope

1.2. Market Definitions

1.2.1. Information analysis

1.2.2. Market formulation & data visualization

1.2.3. Data validation & publishing

1.3. Information Procurement

1.3.1. Primary Others

1.4. Information or Data Analysis

1.5. Market Formulation & Validation

1.6. Market Model

1.7. Objectives

1.7.1. Objective 1

1.7.2. Objective 2

Chapter 2. Executive Summary

2.1. Market Outlook

2.2. Segment Snapshot

2.3. Competitive Landscape Snapshot

Chapter 3. Market Variables, Trends, & Scope

3.1. Market Lineage Outlook

3.1.1. Parent Market Outlook

3.1.2. Related/Ancillary Market Outlook

3.2. Market Trends and Outlook

3.3. Market Dynamics

3.3.1. Patent expiration of blockbuster biologics

3.3.2. Rising demand for monoclonal antibodies

3.3.3. Increasing vaccine production

3.3.4. Technological advancement for the cell line development

3.3.5. Increasing prevalence of cancer

3.3.6. Growing R&D investments in biotechnology sector

3.4. Market Restraint Analysis

3.4.1. Presence of complicated regulatory framework

3.5. Business Environment Analysis

3.5.1. PESTEL Analysis

3.5.2. Porter’s Five Forces Analysis

3.5.3. COVID-19 Impact Analysis

Chapter 4. Product & Services Business Analysis

4.1. Global cell line development market: Product & Services Movement Analysis

4.2. Reagents and media

4.2.1. Reagents and media Market, 2021 - 2033

4.3. Equipment

4.3.1. Equipment Market, 2021 - 2033

4.3.2. Automated Systems

4.3.2.1. Automated Systems Market, 2021 - 2033

4.3.3. Centrifuges

4.3.3.1. Centrifuges Market, 2021 - 2033

4.3.4. Bioreactors

4.3.4.1. Bioreactors Market, 2021 - 2033

4.3.5. Storage equipment

4.3.5.1. Storage equipment Market, 2021 - 2033

4.3.6. Others

4.3.6.1. Others Market, 2021 - 2033

4.4. Accessories and consumables

4.4.1. Accessories and consumables Market, 2021 - 2033

4.5. Services

4.5.1. Services Market, 2021 - 2033

Chapter 5. Source Business Analysis

5.1. Global cell line development market: Source Movement Analysis

5.2. Mammalian cell line

5.2.1. Mammalian cell line Market, 2021 - 2033

5.3. Non-mammalian cell line

5.3.1. Non-mammalian cell line Market, 2021 - 2033

5.3.2. Insects

5.3.2.1. Insects Market, 2021 - 2033

5.3.3. Amphibians

5.3.3.1. Amphibians Market, 2021 - 2033

Chapter 6. Type of Cell Lines Business Analysis

6.1. Global cell line development market: Type of Cell Lines Movement Analysis

6.2. Recombinant cell lines

6.2.1. Recombinant cell lines Market, 2021 - 2033

6.3. Hybridomas

6.3.1. Hybridomas Market, 2021 - 2033

6.4. Continuous cell lines

6.4.1. Continuous cell lines Market, 2021 - 2033

6.5. Primary cell lines

6.5.1. Primary cell lines Market, 2021 - 2033

Chapter 7. Application Business Analysis

7.1. Global cell line development market: Application Movement Analysis

7.2. Bioproduction

7.2.1. Bioproduction Market, 2021 - 2033

7.3. Drug discovery

7.3.1. Drug discovery Market, 2021 - 2033

7.4. Toxicity testing

7.4.1. Toxicity testing Market, 2021 - 2033

7.5. Tissue engineering

7.5.1. Tissue engineering Market, 2021 - 2033

7.6. Others

7.6.1. Others Market, 2021 - 2033

Chapter 8. Regional Business Analysis

8.1. Global Cell line development market Share By Region, 2024 & 2033

8.2. North America

8.2.1. North America cell line development market, 2021 - 2033

8.2.2. U.S.

8.2.2.1. Key Country Dynamics

8.2.2.2. Competitive Scenario

8.2.2.3. Regulatory Framework

8.2.2.4. Target Disease Prevalence

8.2.2.5. U.S. cell line development market, 2021 - 2033

8.2.3. Canada

8.2.3.1. Key Country Dynamics

8.2.3.2. Competitive Scenario

8.2.3.3. Regulatory Framework

8.2.3.4. Target Disease Prevalence

8.2.3.5. Canada cell line development market, 2021 - 2033

8.3. Europe

8.3.1. Europe Cell line development market, 2021 - 2033

8.3.2. Germany

8.3.2.1. Key Country Dynamics

8.3.2.2. Competitive Scenario

8.3.2.3. Regulatory Framework

8.3.2.4. Target Disease Prevalence

8.3.2.5. Germany cell line development market, 2021 - 2033

8.3.3. UK

8.3.3.1. Key Country Dynamics

8.3.3.2. Competitive Scenario

8.3.3.3. Regulatory Framework

8.3.3.4. Target Disease Prevalence

8.3.3.5. UK cell line development market, 2021 - 2033

8.3.4. France

8.3.4.1. Key Country Dynamics

8.3.4.2. Competitive Scenario

8.3.4.3. Regulatory Framework

8.3.4.4. Target Disease Prevalence

8.3.4.5. France cell line development market, 2021 - 2033

8.3.5. Italy

8.3.5.1. Key Country Dynamics

8.3.5.2. Competitive Scenario

8.3.5.3. Regulatory Framework

8.3.5.4. Target Disease Prevalence

8.3.5.5. Italy cell line development market, 2021 - 2033

8.3.6. Spain

8.3.6.1. Key Country Dynamics

8.3.6.2. Competitive Scenario

8.3.6.3. Regulatory Framework

8.3.6.4. Target Disease Prevalence

8.3.6.5. Spain cell line development market, 2021 - 2033

8.3.7. Denmark

8.3.7.1. Key Country Dynamics

8.3.7.2. Competitive Scenario

8.3.7.3. Regulatory Framework

8.3.7.4. Target Disease Prevalence

8.3.7.5. Denmark cell line development market, 2021 - 2033

8.3.8. Sweden

8.3.8.1. Key Country Dynamics

8.3.8.2. Competitive Scenario

8.3.8.3. Regulatory Framework

8.3.8.4. Target Disease Prevalence

8.3.8.5. Sweden cell line development market, 2021 - 2033

8.3.9. Norway

8.3.9.1. Key Country Dynamics

8.3.9.2. Competitive Scenario

8.3.9.3. Regulatory Framework

8.3.9.4. Target Disease Prevalence

8.3.9.5. Norway cell line development market, 2021 - 2033

8.4. Asia Pacific

8.4.1. Asia Pacific cell line development market, 2021 - 2033

8.4.2. Japan

8.4.2.1. Key Country Dynamics

8.4.2.2. Competitive Scenario

8.4.2.3. Regulatory Framework

8.4.2.4. Target Disease Prevalence

8.4.2.5. Japan cell line development market, 2021 - 2033

8.4.3. China

8.4.3.1. Key Country Dynamics

8.4.3.2. Competitive Scenario

8.4.3.3. Regulatory Framework

8.4.3.4. Target Disease Prevalence

8.4.3.5. China cell line development market, 2021 - 2033

8.4.4. India

8.4.4.1. Key Country Dynamics

8.4.4.2. Competitive Scenario

8.4.4.3. Regulatory Framework

8.4.4.4. Target Disease Prevalence

8.4.4.5. India cell line development market, 2021 - 2033

8.4.5. South Korea

8.4.5.1. Key Country Dynamics

8.4.5.2. Competitive Scenario

8.4.5.3. Regulatory Framework

8.4.5.4. Target Disease Prevalence

8.4.5.5. South Korea cell line development market, 2021 - 2033

8.4.6. Australia

8.4.6.1. Key Country Dynamics

8.4.6.2. Competitive Scenario

8.4.6.3. Regulatory Framework

8.4.6.4. Target Disease Prevalence

8.4.6.5. Australia cell line development market, 2021 - 2033

8.4.7. Thailand

8.4.7.1. Key Country Dynamics

8.4.7.2. Competitive Scenario

8.4.7.3. Regulatory Framework

8.4.7.4. Target Disease Prevalence

8.4.7.5. Thailand cell line development market, 2021 - 2033

8.5. Latin America

8.5.1. Latin America cell line development market, 2021 - 2033

8.5.2. Brazil

8.5.2.1. Key Country Dynamics

8.5.2.2. Competitive Scenario

8.5.2.3. Regulatory Framework

8.5.2.4. Target Disease Prevalence

8.5.2.5. Brazil cell line development market, 2021 - 2033

8.5.3. Mexico

8.5.3.1. Key Country Dynamics

8.5.3.2. Competitive Scenario

8.5.3.3. Regulatory Framework

8.5.3.4. Target Disease Prevalence

8.5.3.5. Mexico cell line development market, 2021 - 2033

8.5.4. Argentina

8.5.4.1. Key Country Dynamics

8.5.4.2. Competitive Scenario

8.5.4.3. Regulatory Framework

8.5.4.4. Target Disease Prevalence

8.5.4.5. Argentina cell line development market, 2021 - 2033

8.6. MEA

8.6.1. MEA cell line development market, 2021 - 2033

8.6.2. South Africa

8.6.2.1. Key Country Dynamics

8.6.2.2. Competitive Scenario

8.6.2.3. Regulatory Framework

8.6.2.4. Target Disease Prevalence

8.6.2.5. South Africa cell line development market, 2021 - 2033

8.6.3. Saudi Arabia

8.6.3.1. Key Country Dynamics

8.6.3.2. Competitive Scenario

8.6.3.3. Regulatory Framework

8.6.3.4. Target Disease Prevalence

8.6.3.5. Saudi Arabia cell line development market, 2021 - 2033

8.6.4. UAE

8.6.4.1. Key Country Dynamics

8.6.4.2. Competitive Scenario

8.6.4.3. Regulatory Framework

8.6.4.4. Target Disease Prevalence

8.6.4.5. UAE cell line development market, 2021 - 2033

8.6.5. Kuwait

8.6.5.1. Key Country Dynamics

8.6.5.2. Competitive Scenario

8.6.5.3. Regulatory Framework

8.6.5.4. Target Disease Prevalence

8.6.5.5. Kuwait cell line development market, 2021 - 2033

Chapter 9. Competitive Landscape

9.1. Company Categorization

9.2. Strategy Mapping

9.3. Company Market/PositionShare Analysis, 2022

9.4. Company Profiles/Listing

9.4.1. Thermo Fisher Scientific Inc.

9.4.1.1. Overview

9.4.1.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)

9.4.1.3. Product Benchmarking

9.4.1.4. Strategic Initiatives

9.4.2. Danaher

9.4.2.1. Overview

9.4.2.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)

9.4.2.3. Product Benchmarking

9.4.2.4. Strategic Initiatives

9.4.3. Merck KGaA

9.4.3.1. Overview

9.4.3.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)

9.4.3.3. Product Benchmarking

9.4.3.4. Strategic Initiatives

9.4.4. Sartorius AG

9.4.4.1. Overview

9.4.4.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)

9.4.4.3. Product Benchmarking

9.4.4.4. Strategic Initiatives

9.4.5. Lonza

9.4.5.1. Overview

9.4.5.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)

9.4.5.3. Product Benchmarking

9.4.5.4. Strategic Initiatives

9.4.6. WuXi PharmaTech

9.4.6.1. Overview

9.4.6.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)

9.4.6.3. Product Benchmarking

9.4.6.4. Strategic Initiatives

9.4.7. Advanced Instruments

9.4.7.1. Overview

9.4.7.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)

9.4.7.3. Product Benchmarking

9.4.7.4. Strategic Initiatives

9.4.8. Berkeley Lights

9.4.8.1. Overview

9.4.8.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)

9.4.8.3. Product Benchmarking

9.4.8.4. Strategic Initiatives

9.4.9. Creative BioLabs

9.4.9.1. Overview

9.4.9.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)

9.4.9.3. Product Benchmarking

9.4.9.4. Strategic Initiatives

9.4.10. Corning Inc.

9.4.10.1. Overview

9.4.10.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)

9.4.10.3. Product Benchmarking

9.4.10.4. Strategic Initiatives

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