Congestive Heart Failure Drugs Market Size, Share & Trends Analysis Report By Drug Class (ACE Inhibitors, Angiotensin 2 Receptor Blockers), By Distribution Channel, By Region,- Global Industry Analysis, Share, Growth, Regional Outlook and Forecasts, 2024-2033

The global congestive heart failure drugs market size was exhibited at USD 8.15 billion in 2023 and is projected to hit around USD 34.73 billion by 2033, growing at a CAGR of 15.6% during the forecast period 2024 to 2033.

Key Takeaways:

• North America held the largest share of over 37.0% in 2023.
• The Asia Pacific region is expected to register the highest CAGR of 15.7% over the forecast period.
• The angiotensin-converting enzyme (ACE) inhibitors segment dominated the market in 2023 with a revenue share of over 30.0%. 
• The hospital pharmacies held the largest share of over 57.0% in 2023.
• The online pharmacies segment is expected to expand at a CAGR of 13.6% during the forecast period.

Congestive Heart Failure Drugs Market Report Scope

The market is witnessing growth due to a robust product pipeline, a rising geriatric population, and increasing R&D for drug development. Another major factor facilitating growth is the rising burden of diseases such as obesity, diabetes, hypertension, chronic pulmonary diseases, and renal disease as these are considered CHF-associated prominent co-morbidities. Over the forecast period, the high saturation of generic drugs is expected to slow down the growth. Congestive heart failure (CHF) is a global concern that remains a highly prevalent disorder with a high morbidity and mortality rate. According to the Global Health Data Exchange registry, the global prevalence of disease was around 64.34 million cases, and in the U.S., the prevalence was approximately 5.5 million in 2023.

Currently, pharmacological options for the disease are stepping towards a better treatment approach through product approvals and new product launches. For instance, in February 2023, the FDA approved Boehringer Ingelheim's Jardiance (empagliflozin) to reduce the risk of cardiovascular death and hospitalization in adults. Such new approvals and launches are propelling growth. 

Furthermore, the upsurge in R&D activities and the presence of several drugs under the clinical pipeline create remunerative opportunities and fierce competition among companies. For instance, in February 2023, the FDA accepted NDA for Cytokinetics' drug Omecamtiv Mecarbil, a selective cardiac myosin activator, effective in improving contractility associated with heart failure. CHF clinical trial drugs also include Furoscix infusor, CardiAMP cell therapy, Revascor (Rexlemestrocel-L), semaglutide, tirzepatide, cimlanod, and others. Approval and subsequent launch of such drugs over the coming years are expected to boost the growth. 

Moreover, the increasing burden of diseases such as diabetes and obesity contributes to the rising CHF prevalence over the forecast period. For instance, CDC research studies show a strong association between CHF with diabetes and the increasing hospitalization rate in the U.S. According to the NCBI article, around 35% of CHF patients have diabetes mellitus. 

Amid the pandemic, the clinical trial space witnessed a setback. In addition, the market observed a disturbance in the demand and supply of drugs, and patients faced difficulty accessing healthcare. Government and regulatory authorities imposed restrictions that have delayed clinical trial procedures. However, post the first quarter of 2023, the market regained stability and continued at its regular pace.

Segments Insights:

Congestive Heart Failure Drugs Market By Drug Class Insights 

The angiotensin-converting enzyme (ACE) inhibitors segment dominated the market in 2023 with a revenue share of over 30.0%. This can be due to its effectiveness as an individual treatment or approved combination therapeutic options in the market. Moreover, it is the first choice of treatment for CHF patients. It includes drugs such as Vasotec, Epaned (enalapril), Zestril, Qbrelis, Prinivil (lisinopril), and captopril. Inhibitors block the production of Angiotensin-2, and release arterial pressure, resulting in increased cardiac output without affecting heart rate. This is the most targeted mechanism of action to control heart failure. 

Furthermore, approval of an extended label for sodium-glucose co-transporter 2 (SGLT2) inhibitors for CHF is anticipated to propel the segment growth. For instance, in May 2020, Farxiga (dapagliflozin) and in February 2023, Jardiance (empagliflozin) received label expansion for the treatment of CHF. These SGLT2 inhibitor drugs clinically demonstrated significant cardioprotective benefits and a 35% reduction in hospitalization. The drug class has also demonstrated clinical significance in controlling CHF in patients without diabetes. 

Congestive Heart Failure Drugs Market By Distribution Channel Insights 

The hospital pharmacies held the largest share of over 57.0% in 2023. The retail pharmacies segment is anticipated to witness the highest growth over the forecast period. Retail pharmacies are at ease with most medications, especially in the homecare setting as CHF disease management takes long support of medications. Additionally, CHF drugs are prescription medicines. All these factors favor the growth of the segment.

The online pharmacies segment is expected to expand at a CAGR of 13.6% during the forecast period. Online pharmacy platform encourages the comfort of buying. In addition, in developing countries such as India, companies such as Netmeds Marketplace Ltd. and Tata 1mg promote online medicines buying. However, online buying of prescription drugs is unfavorable to many individuals, which is expected to slow down online pharmacy growth.

Congestive Heart Failure Drugs Market By Regional Insights 

North America held the largest share of over 37.0% in 2023. This can be attributed to the high disease burden, rise in patient awareness, increased healthcare expenditure, and presence of major players in the region. Furthermore, rising approval of new products is expected to fuel the industry growth over the forecast period. 

In the European region, Italy was the least affected, and Germany had the highest CHF prevalence in 2023. The Asia Pacific region is expected to register the highest CAGR of 15.7% over the forecast period. This growth is due to the substantial presence of global companies in this region and the high CHF prevalence in countries such as China, Japan, and Australia. For instance, in 2020, in Australia, the estimated prevalence rate of CHF ranged between 1.2% and 5.3%, majorly due to the rising incidences of diabetes and obesity in the country.

Recent Developments

• In February 2023, AstraZeneca acquired CinCor Pharma, Inc., a US-based clinical-stage biopharmaceutical company. The acquisition bolsters AstraZeneca’s cardiorenal pipeline by adding baxdrostat (CIN-107)for blood pressure lowering in treatment-resistant hypertension to its cardiorenal portfolio.
• In November 2023, Johnson & Johnson signed an agreement to acquire Abiomed. The agreement improved Johnson & Johnson MedTech's (JJMT) position as a growing innovator in cardiovascular innovation, increasing the standard of care for one of healthcare's most pressing unmet disease states: heart failure and recovery.
• In September 2023, Bayer launched vericiguat, a soluble guanylate cyclase (sGC) stimulator in India. Adults dealing with symptomatic chronic heart failure and decreased ejection fraction (less than 45%) are eligible for Vericiguat in addition to guideline-based medical treatment.
• In March 2023, Pfizer Inc. acquired Arena Pharmaceuticals,  a  company that deals in the treatment of several immuno-inflammatory diseases. Arena Pharmaceuticals offers Pfizer a variety of exciting, development-stage pharmaceutical candidates in the fields of cardiology, dermatology, and gastrointestinal.
• In February 2023, Novartis announced that the US Food and Drug Administration (FDA) has approved the expanded use of Entresto to lower the risk of cardiovascular death and heart failure hospitalization in adult patients with chronic heart failure.

Some of the prominent players in the Congestive heart failure drugs market include:

• Bayer AG
• Novartis AG
• Merck & Co., Inc.
• AstraZeneca
• Bristol-Myers Squibb Company
• Amgen Inc.
• Boehringer Ingelheim International GmbH
• Pfizer, Inc.
• Johnson & Johnson Services, Inc.
• Otsuka Pharmaceutical Co., Ltd.
• Eli Lilly and Company
• Novo Nordisk A/S 

Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Nova one advisor, Inc. has segmented the global congestive heart failure drugs market.

Drug Class

• ACE Inhibitors
• Angiotensin 2 Receptor Blockers
• Beta Blockers
• Diuretics
• Aldosterone Antagonists
• Inotropes
• Others

Distribution Channel

• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies

By Region

• North America
• Europe
• Asia-Pacific
• Latin America
• Middle East & Africa (MEA)