Enzymatic DNA Synthesis Market Size, Share & Trends Analysis Report By Service (Oligonucleotide Synthesis, Gene Synthesis), By Application (Synthetic Biology, Genetic Engineering), By End-use, By Region, And Segment)- Global Industry Analysis, Size, Share, Growth, Trends, Regional Outlook, and Forecast 2024-2033

Enzymatic DNA Synthesis Market Size and Growth Forecast 2024-2033

The global enzymatic DNA synthesis market size was valued at USD 233.90 million in 2023 and is anticipated to reach around USD 2,454.34 million by 2033, growing at a CAGR of 26.5% from 2024 to 2033.

Enzymatic DNA Synthesis Market Key Takeaways

• North America dominated the market and accounted for a 50.81% share in 2023
• The enzymatic DNA synthesis market in Asia Pacific is anticipated to witness the fastest CAGR of 27.4% from 2024 to 2033
• The synthetic biology segment dominated the market in terms of revenue in 2023 with a market share of 36.49% and is expected to grow at the fastest CAGR over the forecast period.
• Vaccine development is anticipated to grow at a significant CAGR of 26.7% over the forecast period.
• The oligonucleotide synthesis segment held the largest market share in 2023.
• The gene synthesis segment is expected to grow at the fastest CAGR over the forecast period.
• Biopharmaceutical companies held the largest market share of 48.92% in 2023.
• The contract research organizations segment is expected to witness the fastest CAGR over the forecast period

Enzymatic DNA Synthesis Market Growth 

The advancements in technology, rising demand for precision medicine, increased research in synthetic biology, and greater funding for genetic research and biotechnology are anticipated to drive market growth. Moreover, the expanding biopharmaceutical sector, focusing on innovative drug development and genetic research, is further propelling the market over the forecast period.

The COVID-19 pandemic boosted the market owing to the high demand for fast and accurate testing, vaccines, and treatments. The necessity for quick solutions led to the growing demand for DNA synthesis technology. During the pandemic, this increased focus on medical research and development drove market growth as companies and researchers relied on these technologies to develop vaccines and drugs. Thus, the market's growth for enzymatic DNA synthesis is anticipated to be boosted in the foreseeable period.

The growth of the biopharmaceutical sector is boosting the market. The growing focus on developing new drugs and advancing genetic research increases, propelling the demand for customizable DNA sequences. Enzymatic DNA synthesis offers the precise and efficient DNA construction required for initiating new therapies and conducting advanced research. Moreover, the growing funding for enzymatic DNA synthesis drives biopharmaceutical innovations and is expected to boost market growth significantly during the forecast period.

In addition, technological innovations in enzymatic DNA synthesis speed up the process faster, more accurately, and cost-effectively. These improvements are projected to allow companies to produce DNA sequences quickly and with fewer errors, which is necessary for industries like drug development and genetic research. Technology is enhancing more affordable, initial novel opportunities for a wider range of applications to assist it in services. This is expected to drive the growth and adoption of the enzymatic DNA synthetic market over the forecast period.

Enzymatic DNA Synthesis Market Report Scope

Enzymatic DNA Synthesis Market By Application Insights

The synthetic biology segment dominated the market in terms of revenue in 2023 with a market share of 36.49% and is expected to grow at the fastest CAGR over the forecast period. This is attributed to the rapid advancements and increasing applications of synthetic biology in various fields, including drug development, agriculture, and environmental solutions. Moreover, the ongoing innovations, expanding research applications, and increasing investments in synthetic biology technologies are further anticipated to impel the segment's growth over the forecast period.

Vaccine development is anticipated to grow at a significant CAGR of 26.7% over the forecast period. Synthetic DNA has made way for a generation of cancer vaccines that can be customized to the specific tumor DNA sequence for a patient. Such developments are anticipated to fuel the scientific interest in the technique's utility for vaccine development. Thus, the rising prospects for DNA vaccines that use engineered DNA to induce an immunogenic response against viruses, parasites, cancer, and bacteria are anticipated to drive the segment.

Enzymatic DNA Synthesis Market By Service Insights

The oligonucleotide synthesis segment held the largest market share in 2023 due to its wide range of applications, including genetic research, diagnostics, and therapeutic development. Moreover, the increasing demand for precise and customized oligonucleotides in research and clinical settings, along with advancements in synthesis technologies that enhance efficiency and reduce costs, is further anticipated to contribute to the segment's market growth over the forecast period.

The gene synthesis segment is expected to grow at the fastest CAGR over the forecast period. This is attributed to the increasing applications of gene synthesis in various fields, such as drug discovery, synthetic biology, and personalized medicine. In addition, the growing focus on genetic research and the demand for customized genetic solutions are further propelling the expansion of this segment.

Enzymatic DNA Synthesis Market By End-use Insights

Biopharmaceutical companies held the largest market share of 48.92% in 2023. This is attributed to the growing investments in research and development, which have fueled the demand for advanced enzymatic DNA synthesis technologies. These investments reflect the growing need for innovative solutions in drug discovery and development, further solidifying the segment's leading position and propelling market growth over the forecast period.

The contract research organizations segment is expected to witness the fastest CAGR over the forecast period due to the increasing demand for outsourced research and development services from biotechnology and pharmaceutical companies. In addition, the growing complexity of clinical trials and the need for advanced genetic analysis and diagnostics are further boosting the demand for enzymatic DNA synthesis services provided by CROs.

Enzymatic DNA Synthesis Market By Regional Insights

North America dominated the market and accounted for a 50.81% share in 2023 owing to the growing research infrastructure, high levels of investment in biotechnology, and significant presence of key market players. Moreover, the strong emphasis on innovation and development in genetic research, coupled with substantial funding from both the government and private sectors, has propelled the market's growth over the forecast period.

U.S. Enzymatic DNA Synthesis Market Trends

The enzymatic DNA synthesis market in the U.S. is expected to grow over the forecast period due to growing funding to advance enzymatic DNA synthesis technologies. For instance, in April 2021, the U.S. government invested around USD 1.7 billion in the Association of American Medical Colleges genome sequencing to better detect, monitor, and mitigate COVID variants.

Europe Enzymatic DNA Synthesis Market Trends

The enzymatic DNA synthesis market in Europe was identified as a lucrative region in this industry. Strong research & development in biology, pharmaceuticals, & therapeutics, established research institutions, and a growing number of biotech startups, and the increasing demand for advanced genetic testing in the region are factors driving market growth.

UK enzymatic DNA synthesis market is expected to grow over the forecast period. The ongoing advancement in biomedical research is anticipated to propel the market demand.

The enzymatic DNA synthesis market in France is anticipated to grow over the forecast period. In July 2020, France-based organization DNA Script increased total investment in a Series B round to USD 89 million (EUR 80 million) to support the launch of its DNA printer designed for direct same-day DNA synthesis in labs.

Asia Pacific Enzymatic DNA Synthesis Market Trends

The enzymatic DNA synthesis market in Asia Pacific is anticipated to witness the fastest CAGR of 27.4% from 2024 to 2033 in the enzymatic DNA services market. Rapid advancements in biotechnology, expansion of healthcare infrastructure, rising investments in genomics and personalized medicine, and increasing research activities across the region contribute to the market's growth over the forecast period.

China enzymatic DNA synthesis market is expected to grow over the forecast period. The rise of CROs and the outsourcing of drug discovery and development activities by pharmaceutical and biotech companies are anticipated to drive the market's growth.

The enzymatic DNA synthesis market in Japan is anticipated to grow at a significant CAGR over the forecast period. The growing adoption of precision medicine and personalized healthcare in Japan is boosting the demand for DNA sequencing and gene editing diagnostic applications, thereby expected to propel market growth.

India enzymatic DNA synthesis market is anticipated to grow rapidly over the forecast. This is attributed to the active promotionby the Indian government in the development of biotechnology and healthcare infrastructure.

Middle East And Africa Enzymatic DNA Synthesis Market Trends

The enzymatic DNA synthesis market in the Middle East and Africa is projected to grow in the near future due to the increasing investment in healthcare and biotechnology infrastructure, the growing focus on genomics, and the expansion of research institutions across the region.

Saudi Arabia enzymatic DNA synthesis market is expected to grow over the forecast period due to the growing investmentin biotechnology and life sciences initiatives, including R&D initiatives is expected to drive the demand for enzymatic DNA synthesis in various applications, such as genomics, diagnostics, and therapeutics.

Enzymatic DNA Synthesis Market Top Key Companies:

• Telesis Bio Inc.
• Twist Bioscience Corporation
• GenScript Biotech Corp.
• Evonetix
• Ansa Biotechnologies, Inc.
• Camena Bio
• Molecular Assemblies
• DNA Script
• Touchlight
• Kern Systems

Enzymatic DNA Synthesis Market Recent Developments

• In October 2022, DNA Script announced the expansion of its distribution network to the Middle East to meet the increasing demand for rapid enzymatic DNA synthesis.
• In May 2022, DNA Script announced its partnership with Premas Life Sciences Pvt. Ltd. in India as part of its global expansion to meet the growing demand for rapid enzymatic DNA synthesis.
• In March 2022, Molecular Assemblies, Inc. announced the raise of USD 25.8 million in Series B funding, with new investor Casdin Capital and existing investors, including Agilent Technologies and Codexis, participating. This funding is expected to advance their enzymatic DNA synthesis technology and support a key customer program.

Enzymatic DNA Synthesis Market Report Segmentation

This report forecasts revenue growth at country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Nova one advisor, Inc. has segmented the Enzymatic DNA Synthesis market.

By Service 

• Oligonucleotide Synthesis
• Gene Synthesis

By Application 

• Synthetic Biology
• Genetic Engineering
• Vaccine Development
• Others

By End-use 

• Biopharmaceutical Companies
• Academic & Research Institutes
• Contract Research Organizations

By Region

• North America
• Europe
• Asia-Pacific
• Latin America
• Middle East & Africa (MEA)