The U.S. circulating tumor cells market size was valued at USD 4.85 billion in 2023 and is projected to surpass around USD 16.15 billion by 2033, registering a CAGR of 12.78% over the forecast period of 2024 to 2033.
Some key drivers are increased awareness of cancer treatment and improved healthcare facilities. Technological developments, in addition to specific antigens and biomarkers discoveries, are a few crucial factors contributing majorly to the growth of the Circulating Tumor Cells (CTC) market. Other key factors that boost market growth include the rising incidence of cancer, growing demand for rapid and early-stage cancer diagnosis, advanced facilities, and extensive research.
The U.S. accounted for 39.0% of the global circulating tumor cells market in 2023 owing to key factors such as increased incidence of diseases, rise in drug treatment rate, and high diagnostic prices compared to other developed economies. With the well-established infrastructure of care centers, it is anticipated that there will be an increase in sales of CTC diagnostic tests over the forecast period due to the launch of sophisticated prognosis and diagnosis modalities. In addition, prominent players and several research institutions working on CTC testing kit improvements, advancements in associated technologies, such as drug discovery, cancer diagnostics, personalized medicine, and liquid biopsy, and a well-framed reimbursement structure are expected to enhance the market growth.
Moreover, initiatives undertaken by market players, such as Advanced Cell Diagnostics, Apocell, Inc., and other prominent players to enhance their market hold can be attributed to the large share of the U.S. market. For instance, in October 2022, TellBio, Inc. published data from the scientific founders demonstrating the valuable impact of a new antibody targeting numerous cadherins on tumor cell dissemination in mouse pancreatic and breast cancer models. The growth in cancer-related spending for the introduction of companion diagnostics and personalized medicines is also expected to drive the market over the forecast period. Research organizations are constantly engaged in endeavors to develop CTC-based tests, which can prove helpful in cancer diagnosis.
The ongoing advancements in chip technology have positively impacted market growth. The chip technology helps perform precise CTC isolation but also helps overcome the challenges associated with isolation devices developed by key companies. CTC research is anticipated to grow in demand for tailoring preventive medicine for cancer treatment. For instance, in August 2022, researchers at the Cleveland Clinic in Ohio developed new liquid biopsy tests that can help diagnose cancer before the onset of symptoms by using a nanotube-CTC chip. Such advances are expected to boost the U.S. CTC market.
Report Attribute | Details |
Market Size in 2024 | USD 5.47 Billion |
Market Size by 2033 | USD 16.15 Billion |
Growth Rate From 2024 to 2033 | CAGR of 12.78% |
Base Year | 2023 |
Forecast Period | 2024 to 2033 |
Segments Covered | Technology, application, product, specimen |
Market Analysis (Terms Used) | Value (US$ Million/Billion) or (Volume/Units) |
Report Coverage | Revenue forecast, company ranking, competitive landscape, growth factors, and trends |
Key Companies Profiled | QIAGEN; Bio-Techne Corp.; Precision for Medicine; AVIVA Biosciences; BIOCEPT, Inc.; BioCEP Ltd.; Fluxion Biosciences, Inc.; Greiner Bio-One International GmbH; Ikonisys, Inc.; Miltenyi Biotec; IVDiagnostics; BioFluidica; Canopus Bioscience Ltd.; Biolidics Limited; Creativ MicroTech, Inc.; LungLife AI, Inc.; Epic Sciences; Rarecells Diagnostics; ScreenCell; Menarini Silicon Biosystems; LineaRx, Inc. (Vitatex, Inc.); Sysmex Corporation; STEMCELL Technologies, Inc. |
The blood segment held the largest market share of 47.85% in 2023. CTC detection using blood samples assists in prognosis prediction and determines systemic chemotherapy response. Hence, it is crucial for CTC identification in blood samples and is considered significant in cancer research. Moreover, using untreated whole blood samples is beneficial in enriching CTCs. Technological development for addressing challenges associated with CTC detection in blood samples is expected to drive segment growth further.
The other body fluids segment is expected to witness the fastest CAGR from 2024 to 2033. Several big companies provide blood collection tubes containing preservatives for blood stabilization. Proprietary storage tubes called Cell-Free DNA are available, and CTCs are stable for at least four days at room temperature in these tubes. The most widely used anticoagulant agent in these tubes is EDTA, which stabilizes blood samples by protecting cell viability and allows the study at a genetic and proteomic level, thus enabling biomarker analysis.
The CTC enrichment methods segment held the largest market share of 66.19% in 2023 owing to the wide range of available methods for enriching CTCs in cancer detection. Different techniques for CTC detection include filtration, centrifugal force, magnetic beads-based enrichment, and other physical properties such as size, density, deformity, & electric charges. Positive or negative enrichment of CTC based on biological properties is projected to significantly boost the market growth during the forecast period. Furthermore, a successful enrichment process contributes to sensitivity, selectivity, and yield enhancement while also ensuring positive clinical translation of CTCs.
The CTC analysis segment is expected to witness the fastest CAGR from 2024 to 2033 as it can help clinicians detect underlying reasons for unresponsiveness among patients subjected to targeted therapy. CTC analysis is a minimally invasive method in repetitive analysis and validated technology for tumor study & clinical decision-making. Moreover, technological advancements such as next-generation sequencing (NGS) and immunofluorescence are projected to significantly enhance CTC analyses, further boosting the segment’s growth.
The research segment held the largest market share of 74.17% in 2023 and is expected to register the fastest CAGR during the forecast period. CTCs are a crucial aspect of cancer metastasis and serve as a valuable liquid biopsy material. The enumeration of CTCs is a reliable predictive and prognostic biomarker that can effectively monitor treatment efficacy, detect early metastasis development, and assess therapeutic responses more accurately than traditional imaging methods.
There is a growing focus on characterizing and isolating CTCs, presenting promising opportunities for predictive testing research. Repeated tissue biopsies can get expensive and invasive and are not always feasible. This makes the characterization of CTCs in liquid biopsy an attractive choice to minimize invasiveness and cost. Therefore, the genomic and molecular characterization of CTCs contributes to treatment selection and more personalized treatments.
The kits & reagents segment held the largest market share of 44.21% in 2023. Owing to frequent purchases of these products and their wide usage rates. For instance, the U.S. witnesses a wide usage and production of the CellSearch Circulating Tumour Cell Kit, making it the most popular CTC kit in the country. Several cancer cell lines have been tested by researchers using this kit due to ease of use, and the resultant product of label-free viable cells subsequently used in downstream analysis. In addition, rich product portfolio accessibility coupled with microfluid technological advancements technology is projected to boost further market growth.
The devices or systems segment is expected to witness the fastest CAGR from 2024 to 2033, owing to several advances in microfluidics technology and a wide product portfolio. The fabricated glass microchip’s introduction aiming to overcome challenges and expand technical completeness for mass production is projected to propel segment growth in the upcoming years.
This report forecasts revenue growth at country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Nova one advisor, Inc. has segmented the U.S. Circulating Tumor Cells market.
By Technology
By Application
By Product
By Specimen
Chapter 1. U.S. Circulating Tumor Cells Market: Methodology and Scope
1.1. Market Segmentation & Scope
1.2. Segment Definitions
1.2.1. Technology
1.2.2. Application
1.2.3. Product
1.2.4. Specimen
1.3. Research Methodology
1.4. Information Procurement
1.4.1. Purchased database
1.4.2. nova one advisor internal database
1.4.3. Secondary sources
1.4.4. Primary research
1.4.5. Details of primary research
1.5. Information or Data Analysis
1.5.1. Data analysis models
1.6. Market Formulation & Validation
1.7. Model Details
1.7.1. Commodity flow analysis (Model 1)
1.7.2. Approach 1: Commodity flow approach
1.7.3. Volume price analysis (Model 2)
1.7.4. Approach 2: Volume price analysis
1.8. List of Secondary Sources
1.9. List of Primary Sources
1.10. Objectives
Chapter 2. U.S. Circulating Tumor Cells Market: Executive Summary
2.1. Market Outlook
2.2. Segment Snapshot
2.3. Competitive Insights
Chapter 3. U.S. Circulating Tumor Cells Market: Variables, Trends & Scope
3.1. Market Lineage Outlook
3.1.1. Parent market outlook
3.1.2. Related/ancillary market outlook
3.2. Market Dynamics
3.2.1. Market Driver Analysis
3.2.1.1. Advancements in chip technology
3.2.1.2. Expanding applications of CTCs
3.2.1.3. Growing demand for early and rapid cancer diagnosis
3.2.1.4. Growing incidence of cancer
3.2.2. Market Restraint Analysis
3.2.2.1. Consistency-related challenges in CTC detection and enrichment
3.2.2.2. Higher preference for Point-of-Care (POC) testing and nonavailability of POC adaptable CTC tests
3.2.2.3. Lower applicability of CTCs in rare cancers
3.3. Circulating Tumor Cells Market Analysis Tools
3.3.1. Industry Analysis - Porter’s
3.3.2. PESTEL Analysis
3.3.3. COVID-19 Impact Analysis
Chapter 4. U.S. Circulating Tumor Cells Market: Technology Estimates & Trend Analysis
4.1. Technology Market Share, 2023 & 2030
4.2. U.S. Circulating Tumor Cells Market by Technology Outlook
4.3. Market Size & Forecasts and Trend Analyses, 2021 - 2033 for the following
4.3.1. CTC Detection & Enrichment Methods
4.3.1.1. Market estimates and forecasts, 2021 - 2033
4.3.1.2. Immunocapture (Label-based)
4.3.1.2.1. Market estimates and forecasts, 2021 - 2033
4.3.1.2.2. Positive Selection
4.3.1.2.2.1. Market estimates and forecasts, 2021 - 2033
4.3.1.2.3. Negative Selection
4.3.1.2.3.1. Market estimates and forecasts, 2021 - 2033
4.3.1.3. Size-based Separation (Label-free)
4.3.1.3.1. Market estimates and forecasts, 2021 - 2033
4.3.1.3.2. Membrane-based
4.3.1.3.2.1. Market estimates and forecasts, 2021 - 2033
4.3.1.3.3. Microfluidic-based
4.3.1.3.3.1. Market estimates and forecasts, 2021 - 2033
4.3.1.4. Density-based Separation (Label-free)
4.3.1.4.1. Market estimates and forecasts, 2021 - 2033
4.3.1.5. Combined Methods
4.3.1.5.1. Market estimates and forecasts, 2021 - 2033
4.3.2. CTC Direct Detection Methods
4.3.2.1. Market estimates and forecasts, 2021 - 2033
4.3.2.2. SERS
4.3.2.2.1. Market estimates and forecasts, 2021 - 2033
4.3.2.3. Microscopy
4.3.2.3.1. Market estimates and forecasts, 2021 - 2033
4.3.2.4. Others
4.3.2.4.1. Market estimates and forecasts, 2021 - 2033
4.3.3. CTC Analysis
4.3.3.1. Market estimates and forecasts, 2021 - 2033
Chapter 5. U.S. Circulating Tumor Cells Market: Application Estimates & Trend Analysis
5.1. Application Market Share, 2023 & 2030
5.2. U.S. Circulating Tumor Cells Market by Application Outlook
5.3. Market Size & Forecasts and Trend Analyses, 2021 - 2033 for the following
5.3.1. Clinical/ Liquid Biopsy
5.3.1.1. Market estimates and forecasts, 2021 - 2033
5.3.1.2. Risk Assessment
5.3.1.2.1. Market estimates and forecasts, 2021 - 2033
5.3.1.3. Screening and Monitoring
5.3.1.3.1. Market estimates and forecasts, 2021 - 2033
5.3.2. Research
5.3.2.1. Market estimates and forecasts, 2021 - 2033
5.3.2.2. Cancer Stem Cell & Tumorogenesis Research
5.3.2.2.1. Market estimates and forecasts, 2021 - 2033
5.3.2.3. Drug/Therapy Development
5.3.2.3.1. Market estimates and forecasts, 2021 - 2033
Chapter 6. U.S. Circulating Tumor Cells Market: Product Estimates & Trend Analysis
6.1. Product Market Share, 2023 & 2030
6.2. U.S. Circulating Tumor Cells Market by Product Outlook
6.3. Market Size & Forecasts and Trend Analyses, 2021 - 2033 for the following
6.3.1. Kits & reagents
6.3.1.1. Market estimates and forecasts, 2021 - 2033
6.3.2. Blood collection tubes
6.3.2.1. Market estimates and forecasts, 2021 - 2033
6.3.3. Devices or systems
6.3.3.1. Market estimates and forecasts, 2021 - 2033
Chapter 7. U.S. Circulating Tumor Cells Market: Specimen Estimates & Trend Analysis
7.1. Specimen Market Share, 2023 & 2030
7.2. U.S. Circulating Tumor Cells Market by Specimen Outlook
7.3. Market Size & Forecasts and Trend Analyses, 2021 - 2033 for the following
7.3.1. Blood
7.3.1.1. Market estimates and forecasts, 2021 - 2033
7.3.2. Bone marrow
7.3.2.1. Market estimates and forecasts, 2021 - 2033
7.3.3. Other body fluids
7.3.3.1. Market estimates and forecasts, 2021 - 2033
Chapter 8. Competitive Landscape
8.1. Recent Developments & Impact Analysis, By Key Market Participants
8.2. Company/Competition Categorization
8.3. Vendor Landscape
8.3.1. List of key distributors and channel partners
8.3.2. Key customers
8.3.3. Key company position analysis, 2023
8.4. Company Profiles
8.4.1. QIAGEN
8.4.1.1. Company overview
8.4.1.2. Financial performance
8.4.1.3. Product benchmarking
8.4.1.4. Strategic initiatives
8.4.2. Bio-Techne Corp.
8.4.2.1. Company overview
8.4.2.2. Financial performance
8.4.2.3. Product benchmarking
8.4.2.4. Strategic initiatives
8.4.3. Precision for Medicine
8.4.3.1. Company overview
8.4.3.2. Financial performance
8.4.3.3. Product benchmarking
8.4.3.4. Strategic initiatives
8.4.4. AVIVA Biosciences
8.4.4.1. Company Overview
8.4.4.2. Financial performance
8.4.4.3. Product benchmarking
8.4.4.4. Strategic initiatives
8.4.5. BIOCEPT, Inc.
8.4.5.1. Company overview
8.4.5.2. Financial performance
8.4.5.3. Product benchmarking
8.4.5.4. Strategic initiatives
8.4.6. BioCEP Ltd.
8.4.6.1. Company overview
8.4.6.2. Financial performance
8.4.6.3. Product benchmarking
8.4.6.4. Strategic initiatives
8.4.7. Fluxion Biosciences, Inc.
8.4.7.1. Company overview
8.4.7.2. Financial performance
8.4.7.3. Product benchmarking
8.4.7.4. Strategic initiatives
8.4.8. Greiner Bio-One International GmbH
8.4.8.1. Company overview
8.4.8.2. Financial performance
8.4.8.3. Product benchmarking
8.4.8.4. Strategic initiatives
8.4.9. Ikonisys, Inc.
8.4.9.1. Company overview
8.4.9.2. Financial performance
8.4.9.3. Product benchmarking
8.4.9.4. Strategic initiatives
8.4.10. Miltenyi Biotec
8.4.10.1. Company overview
8.4.10.2. Financial performance
8.4.10.3. Product benchmarking
8.4.10.4. Strategic initiatives
8.4.11. IVDiagnostics
8.4.11.1. Company overview
8.4.11.2. Financial performance
8.4.11.3. Product benchmarking
8.4.11.4. Strategic initiatives
8.4.12. BioFluidica
8.4.12.1. Company overview
8.4.12.2. Financial performance
8.4.12.3. Product benchmarking
8.4.12.4. Strategic initiatives
8.4.13. Canopus Bioscience Ltd.
8.4.13.1. Company overview
8.4.13.2. Financial performance
8.4.13.3. Product benchmarking
8.4.13.4. Strategic initiatives
8.4.14. Biolidics Limited
8.4.14.1. Company overview
8.4.14.2. Financial performance
8.4.14.3. Product benchmarking
8.4.14.4. Strategic initiatives
8.4.15. Creativ MicroTech , Inc.
8.4.15.1. Company overview
8.4.15.2. Financial performance
8.4.15.3. Product benchmarking
8.4.15.4. Strategic initiatives
8.4.16. LungLife AI
8.4.16.1. Company overview
8.4.16.2. Financial performance
8.4.16.3. Product benchmarking
8.4.16.4. Strategic initiatives
8.4.17. Epic Sciences
8.4.17.1. Company overview
8.4.17.2. Financial performance
8.4.17.3. Product benchmarking
8.4.17.4. Strategic initiatives
8.4.18. Rarecells Diagnostics
8.4.18.1. Company overview
8.4.18.2. Financial performance
8.4.18.3. Product benchmarking
8.4.18.4. Strategic initiatives
8.4.19. ScreenCell
8.4.19.1. Company overview
8.4.19.2. Financial performance
8.4.19.3. Product benchmarking
8.4.19.4. Strategic initiatives
8.4.20. Menarini Silicon Biosystems
8.4.20.1. Company overview
8.4.20.2. Financial performance
8.4.20.3. Product benchmarking
8.4.20.4. Strategic initiatives
8.4.21. LineaRx, Inc. (Vitatex, Inc.)
8.4.21.1. Company overview
8.4.21.2. Financial performance
8.4.21.3. Product benchmarking
8.4.21.4. Strategic initiatives
8.4.22. Sysmex Corporation
8.4.22.1. Company overview
8.4.22.2. Financial performance
8.4.22.3. Product benchmarking
8.4.22.4. Strategic initiatives
8.4.23. STEMCELL Technologies, Inc.
8.4.23.1. Company overview
8.4.23.2. Financial performance
8.4.23.3. Product benchmarking
8.4.23.4. Strategic initiatives