U.S. mRNA Synthesis Raw Materials Market Size, Share & Trends Analysis Report, By Type (Capping Agents, Nucleotides, Plasmid DNA), By Application (Vaccine, Therapeutics), By End-use,- Industry Analysis, Size, Share, Growth, Trends, and Forecast 2024-2033

U.S. mRNA Synthesis Raw Materials Market Size and Growth

The U.S. mRNA synthesis raw materials market size was exhibited at USD 842.15 million in 2023 and is projected to hit around USD 1,125.20 million by 2033, growing at a CAGR of 2.94% during the forecast period 2024 to 2033.

Key Takeaways:

• Capping agents held the largest revenue market share of 41.02% in 2023 and is expected to grow at the highest CAGR over the forecast period.
• The nucleotide segment is expected to register a significant CAGR over the forecast period.
• Biopharmaceutical & pharmaceutical companies dominated the segment with a market share of 49.65% in 2023.
• The CROs & CMOs segment is expected to grow at a significant CAGR over the forecast period.
• Vaccine production dominated the segment with a revenue market share of 83.86% in 2023
• The therapeutics segment is expected to grow at a significant CAGR over the forecast period.

Report Scope of U.S. mRNA Synthesis Raw Materials Market

This is attributed to the growing academic & industrial interest in mRNA technology, increasing funding for mRNA research, and raising awareness of the advantages of mRNA-based vaccines. Moreover, the increasing therapeutic applications of RNA technology are anticipated to provide significant demand for mRNA synthesis raw materials over the forecast period.

The COVID-19 pandemic has spurred the rapid adoption of mRNA technology, mainly through mRNA vaccines. Government agencies, research institutions, and pharmaceutical companies are prioritizing the development of efficient COVID-19 detection methods. mRNA vaccines, represented by mRNA-1273 developed by the National Institute of Allergy and Infectious Diseases (NIAID) and Moderna, Inc., have proven highly effective, receiving emergency use authorization from the U.S. FDA in December 2020. This has led to a significant increase in mRNA vaccine usage during the pandemic.

Moreover, RNA centers have been established at numerous institutions to promote therapeutic uses for RNA, particularly In Vitro Transcribed (IVT) mRNA. These facilities include the Yale Center for RNA Science and Medicine, the RNA Institute at the University at Albany, the State University of New York, and the RNA Therapeutic Institute at the University of Massachusetts in the U.S. In addition, university spin-off businesses funded by significant venture capital infusions (such as Argos Medicines, Factor Bioscience, CureVac, Ethris, BioNTech, Moderna, eTheRNA, and Onkaido) have advanced the preclinical and clinical development of mRNA-based therapeutics.

Furthermore, mRNA vaccines direct the cells to produce proteins, driving the demand for mRNA-based vaccines due to the growing awareness among individuals. This, in turn, increases the demand for and surges in adopting mRNA vaccines among patient populations and biotech companies. For instance, in March 2022, a Phase 1 clinical trial was initiated by The National Institutes of Health's NIAID to evaluate three potential HIV vaccines using an mRNA platform.

U.S. mRNA Synthesis Raw Materials Market By Type Insights

Capping agents held the largest revenue market share of 41.02% in 2023 and is expected to grow at the highest CAGR over the forecast period. Capping and tailing are crucial stages in the development of mRNA for use in functional studies. These procedures reduce the translational difficulty and avoid degradation in eukaryotes. Capping agents act as binding molecules or stabilizers to prevent steric hindrance or aggregation. For instance, in September 2022, TriLink BioTechnologies, a manufacturer of raw materials, expanded its GMP-grade product line by offering N1-Methyl-Pseudouridine-5’-Triphosphate (N1meΨTP), an improved Nucleoside-Triphosphate (NTP) necessary for mRNA production. Thus, the increase in the development and launch of novel raw materials to be used in mRNA synthesis is expected to drive market growth.

The nucleotide segment is expected to register a significant CAGR over the forecast period. Nucleotide analogs with unique characteristics would be used as powerful drugs like mRNA-based therapeutics to fight a variety of pathogens or cellular probes. Thus, increasing use of nucleotides in mRNA therapies and drug discovery propelled the market growth.

U.S. mRNA Synthesis Raw Materials Market By End-use Insights

Biopharmaceutical & pharmaceutical companies dominated the segment with a market share of 49.65% in 2023 and is anticipated to grow at the highest CAGR over the forecast period. This is attributed to the increasing demand for the development of new therapeutics due to significant expansions in the pharmaceutical industry pipeline. For instance, according to a study published by Informa in April 2022, there were 46 drugs in the pipeline from Moderna, followed by 29 from BioNTech, 19 from CureVac, 11 from Sanofi, 10 from Pfizer, 5 and 4 from GSK and AstraZeneca, respectively.

The CROs & CMOs segment is expected to grow at a significant CAGR over the forecast period. This fast growth is due to vaccine developers entering into strategic agreements with contract service providers to meet the urgent global demand for mRNA-based vaccines, which led to a sharp increase in the outsourcing industry. In addition, some of the leading outsourcing companies are increasing their finances to strengthen their mRNA synthesis infrastructure and support segment growth. For instance, in June 2022, Vernal Biosciences finished its USD 21 million financing to incorporate its mRNA manufacturing solutions completely.

U.S. mRNA Synthesis Raw Materials Market By Application Insights

Vaccine production dominated the segment with a revenue market share of 83.86% in 2023 and is anticipated to grow at the highest CAGR over the forecast period. This is attributed to the high demand for mRNA vaccines during the COVID-19 pandemic and increased research on mRNA vaccine candidates for several diseases. Moreover, robust product pipelines and a rise in research activities are also supplementing market growth.

The therapeutics segment is expected to grow at a significant CAGR over the forecast period. Rising expenditures by key market players for the production of novel and effective mRNA therapeutics are expected to boost market growth over the forecast years. Moreover, the development and production of mRNA for therapeutic applications are relatively easy, scalable, and incredibly rapid. Due to this, the demand to produce mRNA therapeutics to combat future pandemics has increased gradually over the forecast years.

Recent Developments

• In May 2023, Touchlight completed the redevelopment and expansion of its GMP manufacturing facility in the UK. This move tripled the unit's capacity, which is anticipated to increase the global supply of DNA plasmids for various genetic medicines.
• In July 2023, Applied DNA Sciences, Inc. announced the launch of Linea IVT platform evaluation kits to minimize impurities and lower production expenses for mRNA therapies, such as the COVID-19 vaccines.
• In September 2023, Charles River Laboratories and INADcure collaborated to manufacture gene therapy. The company’s CDMO expertise would enable the production of high-quality plasmids to support Phase I/II clinical trials for Infantile Neuroaxonal Dystrophy.
• In October 2023, Sartorius announced the acquisition of Polyplus, a French company, for a total of 2.4 billion euros (USD 2.6 billion). This acquisition is expected to provide Sartorius with enhanced expertise in nucleic acid delivery, including transfection reagents and plasmid DNA design, which are essential for manufacturing viral vectors for the development of cell and gene therapies.

Some of the prominent players in the U.S. mRNA synthesis raw materials market include:

• F. Hoffmann-La Roche Ltd.
• Jena Bioscience GmbH
• Merck KGaA
• Yeasen Biotechnology (Shanghai) Co., Ltd.
• BOC Sciences
• Thermo Fisher Scientific, Inc.
• Maravai LifeSciences
• New England Biolabs
• Creative Biogene
• HONGENE
• Evonik Industries AG
• GENEVANT SCIENCES CORPORATION

Segments Covered in the Report

This report forecasts revenue growth at country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Nova one advisor, Inc. has segmented the U.S. mRNA synthesis raw materials market

Type

• Capping Agents
• Nucleotides
• Plasmid DNA
• Enzymes

• • Polymerase
  • RNase Inhibitor
  • DNase
  • Others

• Others

Application

• Vaccine Production
• Therapeutics Production
• Others

End-use

• Biopharmaceutical & Pharmaceutical Companies
• CROs & CMOs
• Academic & Research Institutes